The RNA surveillance pathway detects and interprets defective transcripts to ensure RNA fidelity. Recently, in a research report entitled “Oncogenic CDK13 mutations impede nuclear RNA surveillance” published in Science, scientists from Howard Hughes Medical Institute and other institutions discovered a new type of mechanism that affects the occurrence of melanoma, providing broad and important implications for the treatment of various cancer patients.
In the article, the researchers focused on a protein called CDK13, whose important role in cancer development was previously unknown. Researcher Insco said that we found that CDK13 protein can play the role of tumor suppressor in melanoma, and its mutation or deletion can lead to tumor occurrence. By analyzing the data of melanoma patients and the Zon zebrafish model, the researchers clarified that the reason for inducing CDK13 protein deletion or mutation, and revealed its molecular mechanism leading to cancer, including the gene expression behind it.
cell often make mistake in gene expresstion. Researchers have fins that cells produce shortened RNAs, which in tum make taht abnormal protein that induce cancer. Fortunately cells have an active cleanup mechanism to deal with these transcriptions errors. But is cells can not get rid of this garbage,these RNAs can a accumulate and become carcinogens.
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